Custom Peptides
Cayman Chemical 1 2DIpalmItoyl13Csnglycer 10mg
An internal standard for the quantification of 1,2-dipalmitoyl-sn-glycero-3-PC by GC- or LC-MS
Cayman Chemical WAY-208466hydrochlorIde 10mg
A selective 5-HT6 receptor agonist (EC50 = 7.3 nM at the human 5-HT6 receptor); increases cortical GABA levels in rat frontal cortex, producing anxiolytic-like effects in vivo
Cayman Chemical TebIpenm PIvoxIl 10mg
A prodrug form of tebipenem; metabolized by CES in intestinal epithelial cells to form tebipenem; active against methicillin-sensitive and -resistant S. aureus (MIC90s = ≤0.125 and 16 UG/ml, respectively), as well as E. faecalis, E. coli., K. pneumoniae, E. aerogenes, H. influenzae, and P. aeruginosa (MIC90s = 32, 1, 0.5, ≤0.125, 0.25, and 64 UG/ml, respectively); increases survival in mouse models of sepsis induced by S. aureus, E. coli, or P. aeruginosa at 50 and 100 mg/kg
Cayman Chemical PentagastrIn 10mg
A synthetic polypeptide and CCK2 receptor agonist; binds selectively to CCK2 in guinea pig brain over CCK1 receptors in rat pancreas (IC50s = 11 and 1,100 nM, respectively); increases calcium influx and polyphosphoinositide turnover in rat GH3 pituitary cells (EC50s = 23 and 3.9 nM, respectively); increases histidine decarboxylase activity in mucous and endocrine cell-enriched isolated rabbit fundic mucosal cells (EC50 = 2.9 nM); induces contraction of isolated pig ileum smooth muscle cells in vitro (EC50 = 30 pM); increases gastric acid and pepsin secretion in conscious cats in vivo (ED50s = 1.29 and 57.3 nmol/kg2 per hour, respectively)
Cayman Chemical GHVsodIum salt 10mg
An analytical reference standard categorized as a sedative; is an active metabolite of γ-valerolactone; intended for research and forensic applications
Cayman Chemical JP1302hydroCLOrID hydrat 10mg
An α2C-AR antagonist; selective for α2C-ARs over α2A- and α2B-ARs (Kis = 28, 3,150, and 1,470 nM, respectively); reduces immobility time in the forced swim test in mice at 1, 3, and 10 μmol/kg; reverses phencyclidine-induced decreases in prepulse inhibition of the acoustic startle response in rat at 5 mg/kg; dose-dependently reduces haloperidol-induced bradykinesia and catalepsy in mice; increases systolic blood pressure in rats at 0.3 mg/kg
Cayman Chemical Palovaroten 10mg
An orally bioavailable RARγ agonist; increases RARE activity and decreases IL-1β-induced NF-κB activity in primary mouse stromal cells at 60 nM; inhibits activin A-induced chondrogenic and osteogenic differentiation of mouse FAPs expressing ACVR1R206H at 10 nM; inhibits heterotopic ossification and preserves limb movement and growth in a ACVR1R206H FOP mouse model; decreases heterotopic ossification by 50 to 60% in a rat model of traumatic blast injury at 1 mg/kg per day for 14 days
Cayman Chemical MELK-8ahydrochlorIde 10mg
A MELK inhibitor (IC50 = 0.002 µM); selective for MELK over FLT3, haspin, KIT, and PDGFRα, (IC50s = 0.18, 0.19, >10, and 0.42 µM, respectively), as well as a panel of 456 kinases at 1 µM; inhibits the proliferation of MDA-MB-468 and MCF-7 cells (IC50s = 0.11 and 3.68 µM)
Cayman Chemical MEGsulfate 10mg
MEG is a selective iNOS inhibitor and scavenger of peroxynitrite. The EC50 values for inhibition of iNOS (LPS-treated rat lung), eNOS (bovine endothelial), and nNOS (rat brain) are 11.5, 110, and 60 µM, respectively.{7417} MEG reacts with peroxynitrite with a second order rate constant of 1,900 M−1s−1 at 37°C.{4278} MEG has potent anti-inflammatory activity, which may be due to the combined effect of MEG acting as an inhibitor of iNOS and as a scavenger of peroxynitrite.{5922}
Cayman Chemical 1 3-PBITdIhydrobromIde 10mg
A potent inhibitor of iNOS with a Ki value of 47 nM (Ki values for eNOS and nNOS are 9 and 25 µM, respectively)
Cayman Chemical Bullatine B 10mg
A diterpene alkaloid; inhibits Nav1.7 in HEK293 cells expressing the human channel (IC50 = 25.8 nM); scavenges DPPH radicals by 65.3% at 1 mM; increases the mechanical pain threshold in the von Frey test in streptozotocin-induced diabetic, but not non-diabetic, mice at 10 mg/kg
Cayman Chemical olyloyethyl phsphorylchol 10mg
Oleyloxyethyl phosphorylcholine is an inhibitor of PLA2 with an IC50 value of 6.2 µM for porcine pancreatic PLA2.{879}
Cayman Chemical PalmItoylcholInchlorIde 10mg
An acyl choline; inhibits protein kinase C activity at 100 μM; induces hemolysis in rat erythrocytes; plasma levels are decreased in female patients with ME/CFS