Custom Peptides
Cayman Chemical DOTATATE (acetate), Purity: ≥98%, CAS: 177943-89-4, 10 mg
A synthetic peptide; has been conjugated to various radioligands for use in scintigraphy and PET/CT imaging of SST-positive human tumor slices
Cayman Chemical Sisunatovir, Purity: ≥98%, CAS: 1903763-82-5, 10 mg
An RSV fusion inhibitor (IC50 = 0.9 nM); reduces RSV A2 replication in a plaque reduction assay in vitro (EC50 = 1.3 nM); decreases lung viral titers in a mouse model of RSV infection at 1, 10, or 50 mg/kg
Cayman Chemical Omidenepag Isopropyl, Purity: ≥95%, CAS: 1187451-19-9, 10 mg
A prodrug form of omidenepag; reduces IOP in ocular normotensive and laser-induced ocular hypertensive cynomolgus monkeys when topically administered at 0.01%/eye
Cayman Chemical oxLig-1 (technical grade), Purity: ≥80%, CAS: 352523-18-3, 10 mg
A lipid component of oxLDL; binds to the ligand-binding domain of PPARγ, an effect that can be reversed by troglitazone, and also binds to CD36, at 50 µg/ml; increases cholesterol efflux and protein levels of LXRα and ABCA1 in THP-1 macrophages at 20 µg/ml; liposomes containing oxLig-1 and complexed with apolipoprotein H, bind to an anti-apolipoprotein H antibody, which mediates uptake by J774A.1 macrophages; decreases oleic acid-induced intracellular lipid accumulation in HepG2 cells, as well as hepatic lipid accumulation in mice fed a high-fat diet; serum levels of IgG autoantibodies targeting a complex of oxLig-1 and apolipoprotein H are increased in patients with antiphospholipid syndrome with a history of arterial thrombosis
Cayman Chemical MEAI (hydrochloride), Purity: ≥95%, CAS: 81593-54-6, 10 mg
A derivative of MMAI, a psychoactive aminoindane that has been identified in recreational drug mixtures; intended for forensic and research purposes
Cayman Chemical JWH 210 3-ethylnaphthyl isomer, Purity: ≥98%, CAS: 1547339-60-5, 10 mg
A positional isomer of JWH 210, having the ethyl side chain at the 3 position rather than at the 4 position of the naphthyl group; intended for forensic purposes
Cayman Chemical 4-EAPB (hydrochloride), Purity: ≥98%, CAS: 2514946-32-6, 10 mg
An analytical reference standard categorized as a benzofuran; intended for research and forensic applications
Cayman Chemical Gilteritinib, Purity: ≥98%, CAS: 1254053-43-4, 10 mg
A FLT3 inhibitor (IC50 = 5 nM for the wild-type enzyme); inhibits various FLT3 mutants (IC50s = 1.4-12.2 nM); also inhibits Axl and c-Kit (IC50s = 41 and 102 nM, respectively); decreases the viability of blast cells isolated from patients with relapsed AML in a concentration-dependent manner
Cayman Chemical Ruxolitinib (phosphate), Purity: ≥98%, CAS: 1092939-17-7, 10 mg
A potent ATP mimetic that inhibits JAK1 and JAK2 with IC50 values of 2.7 and 4.5 nM, respectively; less selective for JAK3 (IC50 = 322 nM); blocks IL-6 signaling (IC50 = 281 nM) and proliferation of JAK2V617F+ Ba/F3 cells (IC50 = 127 nM); reduces splenomegaly, decreases circulating levels of IL-6 and TNF-α, eliminates neoplastic cells, and prolongs survival in a mouse model of JAK2V617F+ MPN
Cayman Chemical Myristelaidic Acid, Purity: ≥98%, CAS: 50286-30-1, 10 mg
A monounsaturated ω-5 fatty acid; the trans isomer of myristoleic acid; converted to myristelaidoyl CoA at a faster rate than myristoleic acid to myristoleoyl CoA
Cayman Chemical Ginsenoside Rb2, Purity: ≥95%, CAS: 11021-13-9, 10 mg
A natural steroid glycoside with diverse effects; inhibits LPS-stimulated increases in VCAM-1 and ICAM-1 expression; reverses LPS-stimulated decreases in the expression of IκBα in HUVECs in a dose-dependent manner; reduces UVB-induced cytotoxicity and apoptotic nuclear fragmentation in HaCaT cells; lowers total cholesterol and triacylglycerol in 3T3-L1 adipocytes cultured under high fatty acid conditions to levels comparable to lovastatin
Cayman Chemical (1R,9S)-(–)-β-Hydrastine, Purity: ≥98%, CAS: 118-08-1, 10 mg
An inhibitor of dopamine biosynthesis (IC50 = 20.7 µM in PC12 cells); inhibits tyrosine hydroxylase activity; inhibits dopamine release in the presence of a high extracellular K+ level (IC50 = 66.5 µM); inhibits L-type and caffeine-activated store-operated Ca2+ channels; prevents Ca2+ leakage from intracellular stores
Cayman Chemical Cilengitide (trifluoroacetate salt), Purity: ≥98%, CAS: 199807-35-7, 10 mg
An integrin αVβ3 receptor antagonist; inhibits adhesion and induces apoptosis of U87MG and U373MG, but not U251MG cells that lack the integrin αVβ3 receptor, in vitro at a concentration of 20 μg/ml; delays tumor implantation time, reduces tumor growth, and prolongs survival in a U87MG mouse model of glioblastoma when administered at a dose of 200 μg/animal per day
Cayman Chemical JWH 398 5-chloronaphthyl isomer, Purity: ≥98%, CAS: 1427325-89-0, 10 mg
An analytical reference standard that is structurally similar to known synthetic cannabinoids; intended for research and forensic applications
Cayman Chemical Ouabain (hydrate), Purity: ≥98%, CAS: 340169-01-9, 10 mg
A cardiac glycoside with diverse biological activities; inhibits the Na+/K+-ATPase isoforms α1β1 and α2β1 and hERG (IC50s = 97, 90, and 15.2 nM, respectively); reduces the proliferation of PC3 and U937 cells (EC50s = 210 and 94 nM, respectively); inhibits the cytopathic effect of SARS-CoV-2 in infected Vero cells (IC50 = in vivo